Association of protein arginine deiminase 4 with the myosin-9 motor complex.

ABSTRACT: Genetic association data, immunohistochemistry, and functional experiments implicate protein arginine deiminase 4 (PAD4) in the pathogenesis of rheumatoid arthritis (RA). This disease is characterized by immunity against epitopes with deiminated arginine (=citrulline) originating from a multitude of intra- and extracellular proteins that are modified in this manner only in patients with RA, not in healthy individuals. However, it remains uncertain how, where, and why PAD4 citrullinates these proteins in patients with RA. To gain insights into the physical interactions of PAD4 with other cellular proteins, we identified candidate PAD4-associated proteins by mass spectrometry. PAD4 in neutrophils from patients with RA and healthy controls co-immunoprecipitated with myosin-9 and 20 other prot

SUBMITTER: Wang X 

PROVIDER: S-EPMC12390935 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature