Altered gut microbial diversity, composition, and metabolomic potential in patients with major depressive disorder and recent suicide attempt.

ABSTRACT: This study investigates the role of the gut microbiome in suicidal behavior among individuals with major depressive disorder (MDD). Fecal samples from 50 hospitalized patients with MDD, including 35 with recent suicide attempts (60 % female) and 15 without a history of suicide (73 % female), were analyzed using 16S rRNA and shotgun sequencing to assess microbiome diversity and metabolic potential. Results revealed that suicide attempters exhibited significantly greater microbial richness and distinct beta-diversity patterns. Notably, they had higher levels of Fenollaria timonensis and lower levels of Corynebacterium aurimucosum. Additionally, 25 metabolic pathways differed between groups, with several linked to energy metabolism and amino acid processing-processes previously

SUBMITTER: Prandovszky E 

PROVIDER: S-EPMC12390952 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature