Synergistic antibacterial effects of postbiotics combined with linezolid and amikacin against nosocomial pathogens.

ABSTRACT:

Background and aim

The global rise in antimicrobial resistance (AMR) has rendered many conventional antibiotics less effective, particularly against nosocomial pathogens such as Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Proteus mirabilis. This study investigated the antimicrobial and synergistic effects of postbiotics derived from Lacticaseibacillus casei, Lactobacillus bulgaricus, Enterococcus faecium, and Streptococcus thermophilus, administered alone or in combination with either linezolid (for S. aureus) or amikacin (for Gram-negative strains).

Materials and methods

Postbiotics were obtained through anaerobic fermentation, followed by centrifugation and filtration. Cytotoxicity was

SUBMITTER: Yaprak Colak E 

PROVIDER: S-EPMC12390976 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature