Features of mismatch negativity in an at-risk mental state with the traits associated with the autistic spectrum.

ABSTRACT:

Introduction

Accurately distinguishing individuals with autism spectrum disorder (ASD) from those with schizophrenia spectrum disorder (SSD) can be challenging, especially in individuals with an at-risk mental state (ARMS) for psychosis. Given the need for objective markers, we focused on mismatch negativity (MMN). This study aimed to determine whether ARMS individuals with ASD traits exhibit different MMN patterns compared to ARMS individuals without such traits and healthy controls.

Methods

Forty-nine individuals with ARMS and 45 healthy controls were enrolled. The Autism-Spectrum Quotient Japanese Version (AQ-J) was used to assess ASD traits, with a cut-off of 33+ indicating high ASD traits [AQ(+)] and scores below that low ASD traits [AQ(-)]. An electroencephalogram was

SUBMITTER: Kaneko N 

PROVIDER: S-EPMC12390995 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature