Neurofilament light chain concentration mediates the association between regional cortical thickness and Parkinson's disease with excessive daytime sleepiness.

ABSTRACT:

Background

Excessive daytime sleepiness (EDS) is a common non-motor symptom in Parkinson's disease (PD) that negatively impacts quality of life. Although biomarkers of brain structure, function, and neurodegeneration have been studied, their interactions in EDS remain unclear. This study explores the relationship between cortical thickness, functional connectivity (FC), and plasma neurofilament light chain (NfL) levels in PD-EDS.

Methods

36 PD-EDS patients and 100 PD patients without EDS (PD-non-EDS) underwent structural MRI and resting-state FC analysis, with regions of cortical atrophy serving as regions of interest (ROIs). Plasma NfL levels were quantified using high-sensitivity Single Molecule Array (SiMoA™). Mediation analysis was conducted to explore the interplay betw

SUBMITTER: Chen J 

PROVIDER: S-EPMC12391049 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature