Construction and immunohistochemical validation of a necroptosis-related prognostic signature in bladder cancer and its association with tumor immune infiltration.

ABSTRACT:

Background

Bladder urothelial carcinoma (BLCA) represents a highly malignant neoplasm with significant clinical challenges. Necroptosis, a programmed form of cell death, exhibits dual regulatory functions in both tumor immunomodulation and oncogenesis. The precise mechanistic involvement of necroptosis-related genes (NRGs) in BLCA pathogenesis remains poorly characterized, prompting our systematic investigation of their potential biological and clinical significance.

Methods and results

We performed comprehensive bioinformatics analyses utilizing integrated datasets from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database. Through the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation, we curated 159 NRGs and subsequently identified 2

SUBMITTER: Wang T 

PROVIDER: S-EPMC12391097 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature