Hippocampal dysmetabolism contributes to cognitive loss in autoimmune encephalitis and focal temporal epilepsy.

ABSTRACT:

Introduction

Autoimmune encephalitis (AE) is associated with severe cognitive disability. Brain metabolic dysfunction has been linked to encephalopathy in neurodegenerative disorders; however, its role in the development of cognitive loss in AE has not been studied. We hypothesized that cognitively impaired patients with AE will demonstrate altered brain metabolism and immune activation, and these measures will correlate with cognitive scores.

Methods

The hippocampal and cortical metabolites related to neuronal integrity, oxidative metabolism, and glial activation were assessed using single-voxel proton magnetic resonance spectroscopy (1H-MRS) in patients with AE, non-lesional temporal lobe epilepsy (TLE) and control subjects. Metabolite levels were correlated with neuropsyc

SUBMITTER: Taraschenko O 

PROVIDER: S-EPMC12391106 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature