Shared genetic architecture between grip strength and cognitive function: insights from large-scale genome-wide cross-trait analysis.

ABSTRACT:

Background

Physical and cognitive decline are common in older individuals, and traits related to grip strength and cognitive function are used to assess the common genetic structure between the two and to identify common risk loci and genes as well as the genetic mechanisms involved.

Methods

On the basis of large-scale genome-wide association study (GWAS) summary-level datasets, we observed genetic overlaps between grip strength and cognitive function, and cross-trait pleiotropic analysis was performed to detect shared pleiotropic loci and genes. A series of functional annotations and tissue-specific analyses were performed to determine the influence of pleiotropic genes. Heritance enrichment analysis was used to detect crucial immune cells and tissues. Finally, drug targets

SUBMITTER: Liu H 

PROVIDER: S-EPMC12391115 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature