Construction and validation of a necroptosis-related lncRNA signature for predicting the prognosis of gastrointestinal cancer patients.

ABSTRACT:

Background

Given the high incidence and mortality rates of gastrointestinal (GI) cancer, along with the lack of effective prognostic markers, this study aimed to construct a prognostic signature to identify high-risk patients facilitate precision medicine, and ultimately improve patient outcomes.

Methods

We analyzed transcriptomic data for COAD, ESCA, READ, and STAD from the TCGA and GTEx databases. Using co-expression analysis, Cox regression, and least absolute shrinkage and selection operator (LASSO) regression, we developed a necroptosis-related lncRNA signature, termed the Necro-lnc score. The predictive performance of the score was validated and assessed through survival analysis, receiver operating characteristic (ROC) analysis, and Cox regression analysis. Additional

SUBMITTER: Huang W 

PROVIDER: S-EPMC12391139 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature