Intravenous immunoglobulin for the acute treatment of refractory optic neuritis in Japan.

ABSTRACT:

Purpose

To investigate the usage status and evaluate the efficacy of intravenous immunoglobulin (IVIG) for the acute treatment of optic neuritis (ON) in Japan.

Study design

Multicenter retrospective case series.

Methods

The study subjects were patients with steroid-resistant acute ON in whom IVIG had been initiated between January 2020 and August 2022 at 30 facilities in Japan. The clinical characteristics, visual acuity, and adverse events following IVIG were compared among anti-aquaporin 4 antibody positive ON (AQP4-ON), anti-myelin oligodendrocyte glycoprotein antibody positive ON (MOG-ON), and idiopathic ON (ION).

Results

The study included sixty-five patients (76 eyes); the main clinical department administering IVIG was ophthalmology (50 cases, 77.0 %). 4

SUBMITTER: Takahashi Y 

PROVIDER: S-EPMC12391192 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature