Association of plasma levels of protein-bound advanced glycation end-products and their soluble receptors with bone mineral status in young girls with the restrictive type of anorexia nervosa.

ABSTRACT: In diabetes- and age-related osteopenia/osteoporosis, a pathogenetic role of advanced glycation end-products and their soluble receptors (RAGE) is implicated. We studied how these compounds relate to bone health in girls with anorexia nervosa. We found that higher levels of endogenous secretory RAGE were associated with poorer bone quality, warranting further research.

Purpose

We explored the association of plasma protein-bound advanced glycation end-products (AGEs) and their soluble receptors with bone mineralization and turnover markers in girls with a restrictive type of anorexia nervosa.

Methods

A total of 102 girls with anorexia nervosa aged 14.0 ± 2.7 years and 29 age-matched healthy controls were included. Plasma levels of chemically defined AGEs (N^ε-(carbox

SUBMITTER: Sebekova K 

PROVIDER: S-EPMC12391243 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature