Impaired glymphatic function in relation to cumulative blood glucose exposure: A population-based cohort study.

ABSTRACT:

Objective

The relationship between prolonged blood glucose exposure and glymphatic system function of the brain remains unknown. This study aimed to investigate the association between cumulative blood glucose levels and neuroimaging metrics associated with glymphatic function.

Methods

This study was conducted in a multicenter, community-based cohort study. Magnetic resonance imaging (MRI) data were collected once between 2020 and 2022. The assessment of brain glymphatic function can be conducted using the diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index. Cumulative fasting blood glucose (FBG) values from 2014 to 2018 were calculated for each participant as a prolonged exposure, while a single measurement of FBG at the same time of MRI acquisit

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12391268 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature