Vibrio cholerae motility is associated with inter-animal transmission.

ABSTRACT: Outbreaks of cholera are caused by the highly transmissive pathogen Vibrio cholerae. Infant mouse studies have elucidated many aspects of V. cholerae pathogenesis; however, the components of pathogenesis that feed-forward to promote transmission have remained enigmatic because animal models routinely bypass the mechanisms of inter-animal transmission by directly inoculating cultured bacteria into the stomach. Here, a transposon screen reveals that inactivation of the V. cholerae motility-linked gene motV increases infant mouse intestinal colonization. Compared to wild-type V. cholerae, a ΔmotV mutant, which exhibits heightened motility in the form of constitutive straight swimming, localizes to the crypts earlier in infection and over a larger area of the small intestine. Aberrant localiza

SUBMITTER: Campbell IW 

PROVIDER: S-EPMC12391452 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature