Lutein augments the hypoglycemic effect of metformin through the gut microbiota-imidazole propionate axis in type 2 diabetic model mice.

ABSTRACT: Our objective was to investigate the potential of lutein in enhancing the efficacy of metformin in diabetes treatment and the underlying mechanisms involved. Here, the study was conducted with type 2 diabetic mice, which was induced by a high-fat diet with streptozotocin. Twenty-four diabetic model mice were divided into four groups: model control group, metformin group, lutein group, and lutein combined with metformin (Lut_Met) group. Six C57BL/6 mice were assigned to the normal control group and provided a normal chow diet. First, we found that the blood glucose concentration, area of the curve of the oral glucose tolerance test, and homeostasis model assessment for insulin resistance and imidazole propionate (ImP) levels of the Lut_Met group were significantly lower than those of the me

SUBMITTER: Liu K 

PROVIDER: S-EPMC12391467 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature