ECM-based molecular subtypes define prognostic, EMT status, and therapeutic diversity in IDH-mutant gliomas.

ABSTRACT: IDH-mutant gliomas show prognostic heterogeneity despite favorable overall outcomes, necessitating refined molecular classification. While the extracellular matrix (ECM) critically regulates tumor progression, immunity, and EMT, its prognostic significance in IDH-mutant gliomas remains largely unexplored. Here, we employed unsupervised clustering of ECM-related genes across multiple glioma cohorts, identifying two distinct molecular subtypes: ECM1 and ECM2. ECM1 correlated with worse prognosis, characterized by heightened immune infiltration, elevated EMT activity, aggressive radiological features (peritumoral edema/necrosis), and enhanced proliferation, angiogenesis, stemness, and matrix remodeling capacities. A four-gene signature (CLCF1, COL11A1, CSPG5, and SULF1) robustly stratified pa

SUBMITTER: Wei Y 

PROVIDER: S-EPMC12391556 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature