Functional Organization of the Spinal Locomotor Network Based on Analysis of Interneuronal Activity.

ABSTRACT: Locomotion is a vital motor function for any living being. In vertebrates, a basic locomotor pattern is controlled by the spinal locomotor network (SLN). Although SLN has been extensively studied, due to technical difficulties, most data were obtained during fictive locomotion, and data about the activity of spinal neurons during locomotion with intact sensory feedback from limbs are extremely limited. Here, we overcame the technical problems and recorded the activity of putative spinal interneurons from spinal segments L4-L6 during treadmill forward locomotion evoked by stimulation of the mesencephalic locomotor region in the decerebrate cat. We found that neurons were activated and inactivated preferably within one of the four phase ranges presumably related to preparation for the limb l

SUBMITTER: Musienko PE 

PROVIDER: S-EPMC12391573 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature