Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs.

ABSTRACT: The safety of repeated microarray patch (MAP) application is crucial for its development as an innovative drug delivery platform. This study is the first to assess the safety of repeated applications of hydrogel-forming, dissolving, and implantable MAPs over four weeks using miniature pigs, an industry-standard dermatological model with human-like skin structure and physiological responses. Uniform MAPs are successfully manufactured, with application forces of 32 N/array resulting in less than 15% needle height reduction. ≈80% of the needle length penetrated Parafilm layers, while 40-60% penetrated excised porcine skin. Repeated MAP applications do not compromise skin barrier function, as confirmed by transepidermal water loss measurements, and caused no adverse skin reactions per modified

SUBMITTER: Anjani QK 

PROVIDER: S-EPMC12391629 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature