Tumor Microenvironment-responsive Nanocatalyst for Targeted Chemodynamic Cancer Therapy.

ABSTRACT: To address the challenges of insufficient hydrogen peroxide (H₂O₂) levels, rapid Fe³⁺ precipitation, and a slow Fenton reaction cycle, tumor-activated, self-accelerating CDT nanocatalysts are synthesized, comprising poly (lactic-co-glycolic acid) (PLGA)-encapsulated Ca-Fe peroxide clusters and polyarginine (R). Nanocatalysts are camouflaged with cancer cell membranes (CCM) to enhance tumor targeting. Additionally, polyarginine tailored the PLGA responsiveness to low H₂O₂ levels (50-100 µm). H₂O₂ triggered the degradation of PLGA, releasing CaFe clusters to produce Fe³⁺/Fe²⁺ and additional H₂O₂, sustaining the Fenton reaction. Simultaneously, polyarginine releases nitric

SUBMITTER: Ma J 

PROVIDER: S-EPMC12391643 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature