3D Printed Spectroelectrochemical Platform for Redox-Based Bioelectronics.

ABSTRACT: Redox provides unique opportunities for interconverting molecular/biological information into electronic signals. Here, the fabrication of a 3D-printed multiwell device that can be interfaced into existing laboratory instruments (e.g., well-plate readers and microscopes) to enable advanced redox-based spectral and electrochemical capabilities is reported. In the first application, mediated probing is used as a soft sensing method for biomanufacturing: it is shown that electrochemical signal metrics can discern intact mAbs from partially reduced mAb variants (fragmentation), and that these near-real-time electrical measurements correlate to off-line chemical analysis. In the second application, operando spectroelectrochemical measurements are used to characterize a redox-active catechol-bas

SUBMITTER: Chen CY 

PROVIDER: S-EPMC12391658 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature