Glutamate to GABA ratio is elevated in patients with IDH-mutant lower-grade gliomas and seizures.

ABSTRACT:

Background

Patients with IDH-mutant gliomas often experience seizures that significantly affect their quality of life and outcome. Seizure activity may be the result of dysregulation of excitatory (glutamate, Glu) and inhibitory (gamma-aminobutyric acid, GABA) neurotransmitters in peritumoral tissue. A non-invasive measurement of Glu (in combination with glutamine, termed Glx) and GABA is feasible with proton magnetic resonance spectroscopy (¹H-MRS). The aim of this study was to determine whether IDH-mutant glioma patients with seizures exhibit altered Glx and GABA levels compared to patients without seizures.

Methods

We conducted a prospective study involving 23 glioma patients (15 with, 8 without seizures), who underwent single-voxel ¹H-MRS using the

SUBMITTER: Pascuzzo R 

PROVIDER: S-EPMC12391666 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature