Effect of berberine on LPS-induced intestinal epithelial injury and m⁶A methylation in broilers.

ABSTRACT: This study sought to explore the effects of and potential mechanisms underlying berberine (BBR) in lipopolysaccharide (LPS)-induced intestinal epithelium injury in broilers. Ninety 19-day-old male AA broilers were randomly divided into five groups: the negative control group (NC), positive control group (PC), and three treatment groups (T1, T2, and T3). On the 21st day of age, the control group was orally administered saline, the LPS-challenged group was orally administered LPS (3 mg/kg body weight), and the treatment groups were orally administered BBR (6, 12, 18 mg/kg body weight) along with LPS (3 mg/kg body weight). Afterwards, in vitro cell experiments were used for validation. The results revealed that the oral administration of LPS caused intestinal inflammation and cell apoptosis a

SUBMITTER: Yuan L 

PROVIDER: S-EPMC12391687 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature