Effects of high-intensity interval training on physical and cognitive function in middle-aged male mice.

ABSTRACT:

Introduction

Declining functional capacity, both physical and cognitive, is a consequence of aging. However, exercise is a promising intervention to mitigate normal age- related decline. Although numerous studies have elucidated the benefits ofexercise per se, the effect of high-intensity interval training (HIIT) on a middle-aged population is less well-studied.

Objective

Our primary purpose was to assess the effect of 3 months of HIIT on physical and cognitive performance in middle-aged (17-month-old at the end) male C57BL/6J mice compared to sedentary controls (SED). We hypothesized that exercised mice would be resistant to age-related decline in cognitive and physical ability.

Methods

To measure physical function, we used the well-validated comprehensive functional

SUBMITTER: Stephenson JC 

PROVIDER: S-EPMC12391733 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature