A DEL-1/αvβ3 integrin axis promotes brown adipocyte progenitor proliferation and cold-induced brown adipose tissue adaptation.

ABSTRACT:

Objectives

Cold-triggered adaptation of the brown adipose tissue (BAT) promotes increased non-shivering thermogenesis and helps maintain body temperature. This study investigated the role of the secreted protein developmental endothelial locus-1 (DEL-1) in regulating BAT adaptation to cold.

Methods

DEL-1 expression in BAT was assessed following cold exposure in mice. The role of DEL-1 in cold-induced BAT adaptation, thermogenesis and proliferation of brown adipocyte progenitor cells was analyzed by utilizing genetically modified mouse models. Mechanistic insights into DEL-1-mediated regulation of brown adipocyte progenitor proliferation were obtained through in vitro assays.

Results

DEL-1 was expressed in the vascular endothelium of the BAT and its expression was upre

SUBMITTER: Chung KJ 

PROVIDER: S-EPMC12391742 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature