Large-scale network topography of stroke predicts functional outcome after mechanical thrombectomy.

ABSTRACT: Mechanical thrombectomy effectively restores blood flow in patients with acute ischaemic stroke caused by large vessel occlusion. While mechanical thrombectomy has improved functional outcomes, 35%-60% of patients still experience residual disabilities. Typically, patients are selected for mechanical thrombectomy based on degree of hypoperfusion around the core measured on a vascular atlas. This study had two aims: (i) to evaluate the prognostic value of lesion topography onto functional outcome at 3 months post-mechanical thrombectomy, when the lesion is localized either onto a vascular atlas or large-scale, functional or structural, network atlases; and (2) to examine patterns of post-stroke structural and functional disconnection significantly related to the most common stroke functiona

SUBMITTER: Bisogno AL 

PROVIDER: S-EPMC12391757 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature