Immuno-protective cationic ginsenoside Rb1 vesicles for macrophage-mediated targeted therapy of inflammatory diseases.

ABSTRACT: Inflammatory diseases (IDs), characterized by chronic inflammation, are linked to conditions such as bacterial and viral infections, arthritis, and neurodegenerative disorders. Current treatments offer only temporary relief, highlighting the need for more effective therapies. Ginsenoside Rb1 (Rb1), with potent anti-inflammatory and antioxidant properties, can self-assemble into nanoparticles. To enhance targeted therapy for IDs, this study explores the effects of cationic modifications on Rb1 self-assemblies (GRb1). Among the various modifications, polyethylenimine (PEI) (GRb1@PEI) is the most effective at enhancing GRb1's ability to specifically target macrophages. In a murine model of LPS-induced sepsis-related acute lung injury (ALI), PEI facilitates the delivery of Rb1 to sites of infl

SUBMITTER: Luo J 

PROVIDER: S-EPMC12391774 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature