Associations Between Lymphopenia and the Development/Recovery of Acute Kidney Injury Among Patients Hospitalized With Respiratory Virus Infections.

ABSTRACT:

Rationale & objective

Lymphopenia may have a potential mechanism on the development of acute kidney injury (AKI) after respiratory virus infection but has never been revealed. We aimed to investigate the relationship between lymphopenia and AKI in patients hospitalized with respiratory virus infections.

Study & design

A single-center and retrospective cohort study.

Setting & participants

Data were retrospectively collected from electronic medical records of patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza, or other respiratory virus infections from 2016- 2023.

Exposure

Prolonged lymphopenia (<1.1 × 10⁹/L) was defined as continuous lymphopenia lasting for ≥1 day before AKI diagnosis. Serial measurement

SUBMITTER: Fan G 

PROVIDER: S-EPMC12391787 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature