Differential performance of polygenic risk scores for heart disease in Hispanic/Latino subgroups: Findings of the Hispanic Community Health Study/Study of Latinos.

ABSTRACT: Coronary heart disease (CHD) is a leading cause of death among Hispanics/Latinos in the United States (US) whose underrepresentation in genomic research may worsen health disparities. We evaluated predictive performance of polygenic risk scores (PRSs) for myocardial infarction (MI) using data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a cohort of 16,415 participants from 4 US centers. Standardized CHD-PRSs were derived (LDpred, AnnoPred, stacked clumping and thresholding, and LDPred2-GPSmult) and evaluated in survey-weighted Cox models for time to adjudicated MI, adjusted for age, sex, and first 5 principal components. Analyses were stratified by Caribbean (Puerto Rican, Dominican, or Cuban) and Mainland (Mexican, Central American, or South American) heritage. Co

SUBMITTER: Hutten CG 

PROVIDER: S-EPMC12391791 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature