Increased platelet counts are associated with female sex and asthma severity.

ABSTRACT:

Background

Significant sex differences occur in asthma phenotypes across the lifespan. Platelet activation is associated with a steroid-refractory asthma phenotype.

Objective

We sought to test the hypothesis that higher platelet counts in females are associated with increased prevalence and severity of asthma compared with males.

Methods

We conducted a cross-sectional analysis using data from participants' baseline visit in the UK Biobank. Binomial multivariable logistic regression was used to adjust for age, body mass index, sex, race, smoking status, serum C-reactive protein, absolute eosinophil count, and absolute neutrophil count.

Results

Of the 351,203 patients included in the analysis, 5.7% had asthma, 2% met the British Thoracic Society criteria for mode

SUBMITTER: Solanki N 

PROVIDER: S-EPMC12391793 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature