WTAP-mediated m⁶A methylation of circRNA_404908 promotes esophageal squamous cell carcinoma progression.

ABSTRACT: N6-methyladenosine (m⁶A) RNA methylation and circular RNA have been demonstrated to exert a crucial role in diverse malignant tumors, such as esophageal squamous cell carcinoma (ESCC). Nevertheless, the precise regulatory mechanism through which m⁶A-modified circRNA impacts ESCC remains to be elucidated. Herein, we discovered that the methyltransferase Wilms' tumor 1-associated protein (WTAP) is highly expressed in ESCC and is correlated with a poor prognosis. Knockdown of WTAP significantly diminishes the proliferation, migration, and invasion capabilities of ESCC cells both in vitro and in vivo. The m⁶A-circRNA epitranscriptomic microarray analysis, MeRIP-qPCR, RT-qPCR, and circularization verification ascertained that circRNA_404908 is the downstream tar

SUBMITTER: Pan Y 

PROVIDER: S-EPMC12391797 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature