Lipoprotein dynamics in neuromyelitis optica spectrum disorder.

ABSTRACT: Neuromyelitis optica spectrum disorder (NMOSD) is a neuroinflammatory disease caused by aquaporin-4 IgG antibodies, which damage astrocytes and trigger inflammation. Although altered lipid profiles have been observed in various neuroinflammatory diseases, the role of dyslipidemia in NMOSD disease activity remains poorly understood. In this study, we analyzed plasma lipoprotein profiles in 40 patients with NMOSD during relapses, 35 patients with multiple sclerosis (MS) during relapses, and 41 age- and sex-matched healthy controls (HCs). Among 112 lipoprotein components, 39 showed significant alterations in NMOSD patients compared with both MS patients and HCs. These components exhibited consistently lower levels during relapses. Receiver operating characteristic analysis identified total ap

SUBMITTER: Liu TW 

PROVIDER: S-EPMC12391798 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature