The value of white blood cell count and platelet count in predicting delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.

ABSTRACT:

Introduction

Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) contributes significantly to mortality and morbidity. Neuroinflammation and platelet activation are implicated in its pathophysiology.

Research question

This study evaluates the association of admission white blood cell count (WBC) and platelet count (PC), and their combination, with DCI and explores their integration into predictive models.

Materials and methods

This single-center cohort study utilized data from a prospective SAH registry (December 2011-December 2019). Patients with confirmed aSAH and recorded WBC and PC within 72 h post-ictus were included. Univariate and multivariate regression models with established predictors, consisting of the modified Fisher scale (mFS

SUBMITTER: Postma E 

PROVIDER: S-EPMC12391828 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature