A biomimetic nanoplatform for multimodal imaging-guided therapy of esophageal cancer via synergistic activation of cuproptosis and ferroptosis.

ABSTRACT: Esophageal cancer (EC) is a gastrointestinal malignancy with high morbidity and mortality. Traditional treatments yield unsatisfactory outcomes and novel intervention strategy is highly demanded. Cuproptosis and ferroptosis are recently defined modes of cell death, which displays promising utility in cancer treatment. However, their application is hindered due to the tumor inherent antioxidation capacity, absence of tumor-targeting, insufficient efficacy of single mode. To address these limitations, one biomimetic nanoplatform (CM@CDs-Cu₉S₈-GOx, CM@CCG) composed of tumor cell membrane (CM), multifunctional carbon dots (CDs), Cu₉S₈, glucose oxidase (GOx) is proposed and fabricated. It enabled fluorescence (FL), photothermal (PT), and photoacoustic

SUBMITTER: Ren G 

PROVIDER: S-EPMC12391833 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature