Elongation of the nascent avian foregut requires coordination of intrinsic and extrinsic cell behaviors.

ABSTRACT: The foregut tube gives rise to the lungs and upper gastrointestinal tract, enabling vital functions of respiration and digestion. How the foregut tube forms during embryonic development has historically received considerable attention, but over the past few decades this question has primarily been addressed indirectly through studies on morphogenesis of the primitive heart tube, a closely related process. As a result, many aspects of foregut development remain unresolved. Here, we exploit the accessibility of the chick embryo to study the initial formation of the foregut tube, combining embryology with fate mapping, live imaging, and biomechanical analyses. The present study reveals that the foregut forms and elongates over a narrower time window than previously thought, and displays marke

SUBMITTER: Powell O 

PROVIDER: S-EPMC12391882 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature