Comprehensive proteomic characterization of pulmonary arterial hypertension in Chinese people.

ABSTRACT:

Background

Pulmonary arterial hypertension (PAH), a serious disease, is characterized by various degrees of pulmonary vascular remodeling, inflammation, and increased vascular resistance, leading to fatalities in patients with severe conditions. However, the molecular mechanisms underlying the pathogenesis of PAH remain incompletely understood.

Methods

RNA sequencing (RNA-seq), 4D label-free proteomics, and phosphoproteomics were employed to detect the levels of mRNA, proteins, and phosphorylation modification in the lung tissues of PAH patients, compared to those in the control group. Parallel reaction monitoring (PRM) was subsequently performed to verify the differentially expressed proteins (DEPs) identified by proteomic profiling.

Results

After data filtering (|lo

SUBMITTER: Liu T 

PROVIDER: S-EPMC12391885 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature