Maternal Exposure to Carbamazepine at Environmentally Relevant Concentrations Causes Growth Delay in Mouse Embryos.

ABSTRACT: The anticonvulsant drug carbamazepine is ubiquitous in the environment and has even even detected in human urine after consuming produce irrigated with reclaimed wastewater. Whether unintentional carbamazepine exposure through food and water affects public health is unknown. Its potential adverse effects are particularly concerning during pregnancy, as carbamazepine increases the risk of intrauterine growth restriction and congenital malformations in fetuses of carbamazepine-prescribed mothers. While environmental carbamazepine levels are much lower than clinical doses, its impact on early embryonic development, a period highly susceptible to malformations, requires investigation. This study used mice to examine the effect of exposing female mice to environmentally relevant carbamazepine c

SUBMITTER: Veretnik E 

PROVIDER: S-EPMC12391942 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature