Aptamer-Functionalized Redox-Responsive Mesoporous Organosilica-Coated Selenium Nanoparticles for Targeted Therapy of Triple-Negative Breast Cancer Cells.

ABSTRACT: Selenium nanoparticles (SeNPs) exhibit tumor-suppressive capabilities via reactive oxygen species (ROS)-mediated mitochondrial dysfunction, yet their biomedical application remains constrained by poor targeting specificity and aqueous instability. Herein, we engineered glutathione-responsive therapeutic nanoparticles by encapsulating SeNPs within mesoporous organosilica (MON) isolation layers to ensure aqueous stability, while conjugating LXL-1 aptamers for targeted delivery to triple-negative MDA-MB-231 breast cancer cells. In vitro assessments across breast cell lines (MDA-MB-231 vs MCF-10A/MCF-7) revealed a 5.32-fold increase in cellular uptake of functionalized SeNPs in target cells, attributed to aptamer-mediated recognition. The optimized nanoformulation exhibited potent cytotoxicity

SUBMITTER: Xu X 

PROVIDER: S-EPMC12391945 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature