Genome-Wide Identification of Microglia-Related RNA-Binding Proteins and Regulated Alternative Splicing in Spinal Cord Injury.

ABSTRACT: Background: Spinal cord injury (SCI) represents one of the recognized difficulties, and its pathological mechanisms remain unclear. Aberrant regulation of the RNA-binding protein (RBP) and selective splicing are associated with SCI. Nonetheless, the mechanisms of RBP regulation and abnormal selective splicing events associated with SCI are unexplored. Methods: The Spinal Cord Injury Group (GSE185301) dataset and human peripheral blood RNA sequencing (GSE151371) dataset were obtained from the Gene Expression Omnibus (GEO) database. High-throughput sequencing data from sham-operated (Ctrl) and spinal cord injury (SCI) mice were subjected to gene expression profiling and genome-wide identification of differential selective splicing events. SCI-associated selective splicing event

SUBMITTER: Gu W 

PROVIDER: S-EPMC12391951 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature