Targeting Diabetic Complications through Oleuropein-Mediated Enzyme Modulation: A Chemical Biology Study in the Human-Relevant Model <i>Psammomys obesus</i>.

ABSTRACT: This study investigates the therapeutic potential of oleuropein-rich olive leaf extract (OLE) and pure oleuropein compound (OLC) in mitigating diabetes-induced organ damage using Psammomys obesus, a well-established model for metabolic syndrome. Despite the rising global burden of diabetes and associated complications, effective interventions targeting multiorgan dysfunction remain limited. Oleuropein, a polyphenolic compound with documented antioxidant and anti-inflammatory properties, was administered orally at 1 mg/kg body weight over 7 months to six experimental groups subjected to high- or low-calorie diets to simulate diabetic and control conditions. Results demonstrated that the OLE and OLC significantly reduced kidney weight, preserved renal and hepatic histological architec

SUBMITTER: Haffani YZ 

PROVIDER: S-EPMC12391958 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature