A Biomaterial-Based Approach to Trypsin Sensing: Design and Optimization of Gelatin-Casein Films.

ABSTRACT: Real-time postoperative monitoring systems have tremendous potential to detect postoperative complications faster before patients become systemically ill. This study investigates the potential of gelatin-casein blend films as a biodegradable, implantable biomaterial platform for trypsin detection, which is a potential biomarker for an anastomotic leak from the duodenum or proximal jejunum. Although implantability has not been verified in this case, the implantability of gelatin and casein-based biomaterials is substantiated by their demonstrated cytocompatibility as evidenced below and established utility in medical applications, as evidenced by recent advancements in biomaterials research. We systematically evaluated nine gelatin-casein blends, ranging from 0:100 to 100:0 ratios to optimi

SUBMITTER: Ogbonna C 

PROVIDER: S-EPMC12391974 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature