Phloridzin Mitigates Gorham-Stout Disease by Dual Inhibition of Osteoclastogenesis Related to the Ca²⁺ Signaling Pathway and Vascular Proliferation.

ABSTRACT: Phloridzin, a natural compound derived from Malus doumeri, exhibits a wide range of biological activities, making it a promising candidate for the development of functional foods aimed at promoting health and preventing disease. Gorham-Stout disease (GSD) is an orphan rare disorder defined by gradual bone resorption and vascular proliferation, with fewer than 400 cases documented, leading to severe pathological consequences. This study aims to examine the mechanisms underlying two key features of GSD, including progressive osteolysis, through osteoclastogenesis, and vascular proliferation, by examining endothelial and vascular cell proliferation. Additionally, the relationship between phloridzin and GSD was investigated. Our findings demonstrate that PHL suppresses RANKL-induced ost

SUBMITTER: Trang NM 

PROVIDER: S-EPMC12392032 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature