Development of Carborane-Based Benzothiazole Analogues as Cannabinoid Receptor Type 2 (CB₂R) Ligands.

ABSTRACT: The cannabinoid receptor type 2 (CB₂R) is upregulated in the brain under pathological conditions. To distinguish between the healthy and disease states, Positron Emission Tomography (PET), as a noninvasive imaging technique, is employed, for which suitable highly affine and selective CB₂R radioligands are required. The benzothiazole scaffold is a promising core structure that has been modified with different substituents. Recently, we have reported naphthyridinone- and thiazole-based carborane-substituted CB₂R ligands and investigated the first carborane-based CB₂R radiotracer [ ¹⁸ F]-LUZ5- d ₈ in preliminary biological tests. Carboranes are cluster compounds that are used as hydroph

SUBMITTER: Ueberham L 

PROVIDER: S-EPMC12392035 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature