Midlife Steroid-Binding Globulin Levels and In Vivo Neuroimaging Measures of Tau in Older Men and Women.

ABSTRACT:

Objective

In men and women, sex steroid hormones have been associated with increased risk of Alzheimer's disease (AD) dementia. We aimed to investigate the influence of midlife testosterone and sex hormone binding globulin (SHBG) levels on later-life in vivo markers of β-amyloid (Aβ) and tau deposition in clinically healthy older men.

Methods

This time-lagged study includes participants enrolled in the Framingham Heart Study (FHS) Third Generation cohort. One hundred fifty-nine men (mean age_PET-scan = 58 [±/9] years) underwent blood (hormones) collection in 2002 to 2005, and then a single Aβ ¹¹C-Pittsburgh Compound B (PiB) PiB-positron emission tomography (PET) and ¹⁸F-Flortaucipir (FTP)-PET scan in 2016 to 2020. Linear regressions examined s

SUBMITTER: Buckley RF 

PROVIDER: S-EPMC12392056 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature