NMR-Based Serum Metabolomics and Correlation Analysis Unraveled Metabolic Alterations Underlying Pathophysiology of Type 2 Diabetes Mellitus.

ABSTRACT: Type 2 diabetes mellitus (T2DM) is a growing global health concern, with a high prevalence among individuals aged 45-50 years and above. Chronic inflammation, oxidative stress, and mitochondrial dysfunction play pivotal roles in its progression. This clinical metabolomics study aimed to identify distinct metabolic alterations associated with insulin resistance and other clinical features of T2DM. Fasting serum samples from 43 T2DM patients (mean age 51 ± 9 years) and 34 age- and sex-matched controls (mean age 49 ± 11 years) were analyzed using 800 MHz NMR spectroscopy. Serum metabolite concentrations were quantified using CHENOMX software and compared using multivariate and univariate statistical methods, with the diagnostic potential evaluated through receiver operating characteristic (RO

SUBMITTER: Trivedi R 

PROVIDER: S-EPMC12392183 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature