Pesticide Levels and Other Etiopathogenetic Factors in Patients with Chronic Kidney Disease of Unknown Cause in Central India - A Case-Control Study.

ABSTRACT:

Background

The etiology of chronic kidney disease of unknown cause (CKDu) remains unexplained, with environmental toxins, i.e., heavy metals and pesticides. being explored for their causal role. We measured pesticide levels in blood and urine in patients with CKDu in central India. We compared them with healthy and chronic kidney disease (CKD) controls.

Materials and methods

This case-control study compared patients with CKDu (n = 55), CKD (n = 53) and healthy controls (n = 50). Levels of 6 organophosphates (OPs) and 16 organochlorines were measured by GC-MS. Drinking water sources and pesticide use, and hours spent in sunlight were also evaluated.

Results

CKDu and CKD subjects were age and sex matched. CKDu and CKD subjects had higher median chlorpyrifos (CP) 3.69 (2

SUBMITTER: Atlani M 

PROVIDER: S-EPMC12392190 | biostudies-literature | 2025 Jul-Aug

REPOSITORIES: biostudies-literature