Post Transplant Membranous Nephropathy: A 10-year Single-Centre Experience.

ABSTRACT: Membranous nephropathy (MN) post-renal transplant can present as a recurrent or de novo disease, often impacting graft outcomes. We retrospectively analyzed 530 allograft biopsies over 10 years, identifying five MN cases (∼1%): four de novo (0.8%) and one recurrent. Among the former, 75% had concurrent antibody-mediated rejection (AMR); serum anti-PLA2R and tissue PLA2R were detected in 25%. All patients received plasmapheresis and low-dose intravenous immunoglobulin, with one requiring rituximab. Two patients stabilized, one experienced graft loss, and one attained complete remission. The recurrent MN case presented 10 years post-transplant and partially responded to rituximab. AMR influenced prognosis, with a 33% graft loss rate in de novo MN. Individualized treatmen

SUBMITTER: Gaggar P 

PROVIDER: S-EPMC12392203 | biostudies-literature | 2025 Jul-Aug

REPOSITORIES: biostudies-literature