Self-Assembled Three-Dimensional Au Films as Highly Reproducible and "Hotspots"-Rich Substrates for Multiplex SERS Detection.

ABSTRACT: Three-dimensional (3D) plasmonic metal nanostructures show great promise for surface-enhanced Raman scattering (SERS) detection of analyte molecules. However, obtaining uniform "hotspots" is still a paramount challenge. Herein, we report a low-cost strategy for the scalable preparation of 3D Au films with a high density of "hotspots" using a deep eutectic solvent (DES)-mediated interfacial self-assembly of thermally evaporated Au NPs. Owing to the hydrogen-bonded structure of DES, the size and morphology of the self-assembled Au films can be precisely controlled. The as-prepared 3D Au substrate exhibits outstanding SERS detection for various analyte molecules such as crystal violet (CV), rhodamine 6G (R6G), and 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB) with a limit of detection (LOD) as l

SUBMITTER: Carreon RV 

PROVIDER: S-EPMC12392253 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature