Retinoic acid receptor-related orphan receptor α regulates bystander activation of memory CD8⁺ T cells.

ABSTRACT:

Background

Memory CD8⁺ T cells sense inflammation and rapidly produce interferon-γ (IFN-γ) independent of cognate antigens. This innate-like property, called bystander activation, is involved in early host defense before the antigen-specific memory response. However, the molecular mechanisms underlying this activation remain unknown. Retinoic acid receptor-related orphan receptor α (RORα) belongs to the nuclear receptor family and regulates gene transcription in ligand-dependent manner. Although RORα is highly expressed in memory CD8⁺ T cells, its functional relevance has not been investigated.

Methods

Primary and secondary memory T cells that are sufficient or deficient of RORα were induced by adoptive transfer of naïve OT-I T cells to recipient mice a

SUBMITTER: Cai Z 

PROVIDER: S-EPMC12392277 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature