Cutaneous extranodal NK/T cell lymphoma: heterogeneity of spatial transcriptomic profiling according to primary tumor site.

ABSTRACT:

Introduction

Extranodal NK/T-cell lymphoma (ENKTL) with cutaneous involvement can be divided into primary cutaneous ENKTL (pcENKTL) and secondary cutaneous involvement (scENKTL). Despite different originations, the clinical and histopathological findings are indistinguishable. Moreover, the prognosis determinants in each entity have yet to be established. We investigated differences in spatially resolved transcriptome profiles between pcENKTL and scENKTL.

Materials and methods

Seven samples with 24 regions of interest were selected for pcENKTCL and scENKTL, using CD56 and CD3 morphology markers.

Results

In CD56-positive tumor cell areas, we detected 91 upregulated differentially expressed genes (DEGs) and 27 downregulated DEGs in pcENKTL compared with scENKTL. Protein

SUBMITTER: Choi ME 

PROVIDER: S-EPMC12392331 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature