Biomarkers for early detection and monitoring of abnormal brain development in mild fetal growth restriction.

ABSTRACT: Fetal growth restriction (FGR), driven by intrauterine hypoperfusion, delays brain development and heightens the risk of neurodevelopmental disorders. Nonetheless, current diagnostic strategies rarely capture the subtle neuropathology that emerges in mild FGR. To overcome this limitation, we employed an innovative rodent model that replicates mild FGR through gradual and chronic intrauterine hypoperfusion, mirroring clinical conditions overlooked by conventional severe or acute FGR models. Global proteomics of cerebrospinal fluid identified Alpha-2-Macroglobulin, Neuroserpin, CD200, and Polyubiquitin-B as biomarkers correlated with birth weight and persisting postnatally. Their expression reflected changes in brain tissue and serum, was associated with behavioral deficits, and partially re

SUBMITTER: Onoda A 

PROVIDER: S-EPMC12392332 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature