Photothermal-gas combination therapy promotes checkpoint blockade immunotherapy in colon cancer.

ABSTRACT: Checkpoint blockade immunotherapy emerges as a potential cure of cancer, but the monotherapy suffers from a low response rate in clinic. Photothermal therapy (PTT) that harvests light energy to ablate tumor is reported to activate tumor-specific immune response, meanwhile nitric oxide (NO) is considered to involve in immune regulation. Herein, we designed a multifunctional nanoplatform that enables photothermal-gas combination therapy by conjugating indocyanine green-thiol (ICG-SH) and s-nitrosoglutathione (GSNO) onto polyvinyl pyrrolidone (PVP)-coated gold nanoparticles (AIG). Upon near-infrared light (NIR) irradiation, AIG heats up the cancer cells and triggers NO release from GSNO, thus inducing apoptosis in the tumor. We found the combination of NO with photothermal treatment causes im

SUBMITTER: Zheng B 

PROVIDER: S-EPMC12392434 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature